首页分享从丹参花中分离和鉴定抗氧化成分。

从丹参花中分离和鉴定抗氧化成分。

来源：花匠小妙招时间：2025-04-21 23:54

从丹参花中分离和鉴定抗氧化成分。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

引用次数: 0

摘要

从丹参花的正丁醇馏分中获得了一种新的丹酚酸衍生物--(7'E)-(7S, 8S)-丹酚酸 V (1)，以及之前描述过的四种化合物(2-5)。通过一系列光谱方法确定了它们的结构，并通过电子圆二色性（ECD）计算确定了 1 的绝对构型。丹酚酸（1）和酚酸（2-4）具有较强的 DPPH 自由基清除能力，对 H2O2 诱导的人皮肤成纤维细胞（HSF）氧化损伤具有一定的保护作用，其中化合物 1（IC50 7.12 μM）比阳性对照维生素 C（IC50 14.98 μM）具有更明显的自由基清除活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Isolation and identification of antioxidant constituents from the flowers of Salvia miltiorrhiza

A new salvianolic acid derivative, (7′E)-(7S, 8S)-salvianolic acid V (1), together with four previously described compounds (2-5) were obtained from the n-butanol fraction of Salvia miltiorrhiza flowers. Their structures were established by a series of spectroscopic methods, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) calculation. Salvianolic acids (1) and phenolic acids (2-4) showed stronger DPPH free radical scavenging abilities and certain protective effects against H2O2-induced human skin fibroblast (HSF) cells oxidative damage, in which compound 1 (IC50 7.12 μM) possessed more noticeable free radical scavenging activity than the positive control vitamin C (IC50 14.98 μM).

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来源期刊

Natural Product Research

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.