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基于知识图谱和全球专利的贝母属植物研究现状与发展趋势的可视化分析

来源：花匠小妙招时间：2026-02-26 20:40

[关键词]

[摘要]

目的运用文献计量学方法分析贝母属Fritillaria植物的研究现状与发展趋势，并通过专利分析得到贝母属植物的成果转化情况，为未来的开发应用提供方向参考。方法在中国知网数据库、万方数据库、维普数据库、Web of Science核心合集数据库，以贝母和Fritillaria为主题检索词收集相关文献，导入NoteExpress文献管理软件中进行查重、筛选和格式转换；使用Excel、CiteSpace、VOSviewer软件对中英文文献的年度发文趋势、合作网络、研究热点等进行可视化分析。通过Incopat专利数据库从专利申请趋势、专利申请地域分布、专利申请人等方面对贝母属植物专利申请情况进行分析。结果共纳入符合标准的中文文献1 511篇，英文文献805篇。贝母属发文量大体呈现上升的趋势，共有56个国家参与贝母属的研究，发文国家以中国为主。英文文献涉及学科以植物科学为主。中、英文发文量最多的作者分别是周浓和Li Ping，最多的机构分别是中国中医科学院和Chinese Academy of Sciences（中国科学院），部分发文作者间已形成研究团队，发文机构间的合作关系较分散。基于Incopat专利数据库检索得到专利数据10 292件，国内专利有9 980件，占比96.97%，占据绝对的主导地位。结论贝母属植物的研究处于不断拓展与上升阶段，其研究核心物种为浙贝母和川贝母，热点方向为生物碱等活性成分、药理作用与分子机制、生长栽培与资源保护等。贝母属植物专利在全球分布差距明显，我国的专利申请量占据绝对主导地位，但当前仍面临申请活跃度不足、有效率较低、技术构成单一以及竞争力不强等问题。

[Key word]

[Abstract]

Objective To analyse the current research status and development trend of Fritillaria plants using bibliometric methods, and obtain the transformation achievement of Fritillaria plants through patent analysis, providing direction reference for future development and application. Methods Relevant literature were searched and collected from four databases, namely CNKI Database, Wanfang Database, VIP Database and Web of Science Core Collection Database with Fritillaria spp. and Fritillaria as the subject search terms. The data were imported into NoteExpress literature management software for duplicate checking, screening and format conversion. Excel, CiteSpace, and VOSviewer were used to visualize and analyze the annual publication trends, cooperation networks, and research hotspots of Chinese and English literature. The patent application status of Fritillaria plants was analyzed through the Incopat patent database from the aspects of patent application trends, geographical distribution of patent applications, and patent applicants. Results The dataset encompasses 1 511 Chinese articles and 805 English articles. The number of publications of Fritillaria plants has generally shown an upward trend, with a total of 56 countries participating in the study of Fritillaria plants, with China being the main publishing country. The primary discipline in English literature was plant science. The authors with the largest number of publications are Zhou Nong in Chinese literature and Li Ping in English literature. In Chinese literature, the China Academy of Chinese Medical Sciences leads. Among English publications, the Chinese Academy of Sciences dominates. Some of the authors of the published papers have formed research teams, while the cooperative relationships among the publishing institutions are relatively scattered. Based on the Incopat patent database, 10 292 patent applications were retrieved. Among these patents, 9 980 patents were domestic patents, accounting for 96.97%, occupying an absolute dominant position. Conclusion Research on Fritillaria plants is in the stage of continuous expansion and upward, and the core species of Fritillaria plants are Fritillaria thunbergii Miq. and Fritillaria cirrhosa D. Don, and the hotspots are active ingredients such as alkaloids, pharmacological effects and molecular mechanisms, growth and cultivation and resource protection. The global distribution gap of Fritillaria plant patents is obvious, China’s patent applications occupy an absolute dominant position, but it still faces problems such as low application activity, low validity rate, single technical composition, and weak competitiveness.

[中图分类号]

G350;R282

[基金项目]

江苏省中医疫病研究中心开放课题(JSYB2024KF28); 无锡市中医药科技发展专项重点项目(ZYZD202404); 江苏省中医流派研究院开放课题一般项目(JSZYLP2024040); 无锡市卫生健康委科研面上项目(M202329)

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陈琼如,夏清青,张宇锋,计婷婷,王进,花海兵.基于知识图谱和全球专利的贝母属植物研究现状与发展趋势的可视化分析[J].中草药,2025,56(22):8296-8314

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