多酚类化合物:一种海洋巨藻海绵藻内生菌的抗菌脂类化合物

多酚类化合物:一种海洋巨藻海绵藻内生菌的抗菌脂类化合物

Nicholas J. Morehouse, Andrew J. Flewelling, Dennis Y. Liu, Hannah Cavanagh, Roger G. Linington, John A. Johnson and Christopher A. Gray*, 

摘要

从海绵藻内生真菌中分离到两个新的脂基化合物:糖基化合物A(1)和B(2)，以及nrps -聚酮-shikimate天然混合产物maximiscin [(P/M)-3)]。核磁共振和质谱分析数据揭示了脂基的氨基酸序列，它们都包含11个残基，在n端有一个缬氨酸c端和一个癸醇酰基链。氨基酸的结构由Marfey的分析确定。多糖A(1)和B(2)对革兰氏阳性和抗酸菌株表现出中等的选择性抑制作用，而最大化霉素[(P/M)-3)]表现出中等的广谱抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tolypocaibols: Antibacterial Lipopeptaibols from a Tolypocladium sp. Endophyte of the Marine Macroalga Spongomorpha arcta

Two new lipopeptaibols, tolypocaibols A (1) and B (2), and the mixed NRPS-polyketide-shikimate natural product maximiscin [(P/M)-3)] were isolated from a Tolypocladium sp. fungal endophyte of the marine alga Spongomorpha arcta. Analysis of NMR and mass spectrometry data revealed the amino acid sequences of the lipopeptaibols, which both comprise 11 residues with a valinol C-terminus and a decanoyl acyl chain at the N-terminus. The configuration of the amino acids was determined by Marfey’s analysis. Tolypocaibols A (1) and B (2) showed moderate, selective inhibition against Gram-positive and acid-fast bacterial strains, while maximiscin [(P/M)-3)] showed moderate, broad-spectrum antibiotic activity.

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来源期刊

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.

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