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来源：花匠小妙招时间：2024-11-18 04:59

SARS-CoV-2回顾：流行病学、病理生理学和传统医药的潜在防治措施

作者:

Munit Sharma

Assistant Professor, Department of Botany, Thakur P.G. College of Education, Dhaliara-177103, Dehra, Himachal Pradesh, India
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作者单位:

Assistant Professor, Department of Botany, Thakur P.G. College of Education, Dhaliara-177103, Dehra, Himachal Pradesh, India

Reviewing the insights of SARS-CoV-2: Its epidemiology, pathophysiology, and potential preventive measures in traditional medicinal system

Author:

Munit Sharma

Assistant Professor, Department of Botany, Thakur P.G. College of Education, Dhaliara-177103, Dehra, Himachal Pradesh, India
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Affiliation:

Assistant Professor, Department of Botany, Thakur P.G. College of Education, Dhaliara-177103, Dehra, Himachal Pradesh, India

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摘要:

背景：2019年12月底首次报告了引起COVID-19病毒感染的严重急性呼吸综合征冠状病毒-2，其迅速蔓延到其他国家。世卫组织（WHO）于2020年3月宣布其为大流行病。由于病毒爆发，全球医疗系统和经济负担出现了许多问题。高传播率和传染性使COVID-19成为大流行病。有效管控疫情传播具有挑战性。尽管各方为遏制COVID-19的爆发做出了巨大努力，但疫情仍不断恶化，并缺少该疾病的预防方式。为COVID-19开发有效的治疗方法一直是一项复杂而持续的工作。目的：该系统综述旨在评估严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）病毒的结构、流行病学、病理生理学、潜在的治疗方法以及传统医药中的预防和治疗措施。方法：该研究采用了符合PRISMA指南的系统方法。在2010-2023年期间，在ScienceDirect、Google Scholar、PubMed和ResearchGate等各种数据库中搜索了“COVID-19”、“SARS-CoV-2”、“Coronavirus”和“Traditional Chinese Medicine”等关键词。通过遵循PRISMA方法的系统搜索策略，确定了与该研究相关的临床试验和研究。结果：该综述通过PRISMA指南对文献进行仔细评估和审查后，纳入了145项相关研究，详细研究总结了病毒结构、病因、流行病学特征、病理生理学，以及传统医学体系在治疗COVID-19感染者时可能采用的治疗方法和预防措施。结论：病因分析揭示了SARS-CoV-2的传播动态和发病机制。COVID-19的症状和严重的疾病预后可通过某些发现了新适应症的药物、传统医药系统和抗病毒药物来控制，这些药物已被证明可有效治疗COVID-19感染。

Abstract:

Background The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019, spreading swiftly across all over the world. WHO declared it a pandemic by March 2020. Many problems emerged worldwide healthcare system and economic burden due to viral outbreak. High transmission rate and infectious nature make COVID-19 pandemic. Effectively managing outbreak and controlling spread is challenging. Despite valiant efforts to contain the COVID-19 outbreak, the situation has deteriorated to the point that there were no viable preventive therapies to treat this disease. Developing effective treatment for COVID-19 has been a complex and ongoing endeavor. Objective The aim of this systematic review is to evaluate the structure, epidemiology, pathophysiology, potential therapeutic treatments, and preventive measures adopted in Traditional Chinese Medicine (TCM) in the management of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Methods A systematic methodology has been adopted in this study following PRISMA guidelines. Several keywords like “COVID-19” “SARS-CoV-2” “Coronavirus” and “Traditional Chinese Medicine” were searched in various databases like ScienceDirect, Google Scholar, PubMed, and ResearchGate during the time span of 2010 – 2023. Clinical trials and studies relevant to this study were identified through a systematic search strategy following PRISMA methodology. Results In this systematic review, after careful evaluation and reviewing of literature through PRISMA guidelines, 145 relevant studies were identified, reviewed and included in this systematic review. A detailed study has been summarized on virus structure, etiology, epidemiology characteristics, pathophysiology, and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 patients. Conclusion SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology analysis. COVID-19 symptoms and severe disease outcomes can be managed with certain repurposed drugs, traditional medicinal system and antivirals, which have been shown to be effective in treating COVID-19 infection.