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Ginkgetin (银杏双黄酮)

来源：花匠小妙招时间：2026-02-12 19:05

生物活性

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ[1][2][3][4][5].

细胞效力
(Cellular Effect)

OVCAR-3

Cell Line Type Value Description References OVCAR-3 IC50

1.8 μg/mL

Compound: 1

Growth inhibition of human OVCAR-3 cells after 48 hrs

[PMID: 9134745] 体外研究
(In Vitro)

Ginkgetin (1-10 μM；24 或 48 h) 以浓度依赖性方式显著抑制 VEGF 诱导的内皮细胞增殖、迁移和伤口愈合[1]。
Ginkgetin (2.5-20 μM；48 h) 抑制 Daoy 和 D283 细胞系的生长，并诱导 Daoy 细胞发生 G2/M 期细胞周期阻滞[2]。
Ginkgetin (20-40 μM；24 h) 以浓度依赖性方式显著激活骨肉瘤细胞的凋亡[3]。
Ginkgetin (10-20 μM；3-24 h) 下调髓母细胞瘤细胞中 Wnt 靶基因的表达，而不影响 β-catenin 的表达[2]。
Ginkgetin (5-10 μM；48 h) 在 A549 细胞中诱导与细胞死亡相关的自噬[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Daoy and D283 cell lines Concentration: 2.5, 5, 10, 20 μM Incubation Time: 48 hours Result: Inhibited the cell growth, with IC50s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

Apoptosis Analysis[3]

Cell Line: Osteosarcoma cells Concentration: 20, 30, 40 μM Incubation Time: 24 hours Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

Cell Cycle Analysis[2]

Cell Line: Daoy cells Concentration: 2.5, 5, 10, 20 μM Incubation Time: 24 hours Result: Increased G2/M phase, compared with that of control, indicating a G2/M cell phase arrest.

Cell Cycle Analysis[2]

Cell Line: Daoy and D283 cell lines Concentration: 10, 20 μM Incubation Time: 3, 6, 12, 24 hours Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner. 体内研究
(In Vivo)

Ginkgetin (25-100 mg/kg；腹腔注射，在缺血发作后 2 小时给药) 通过 TLR4/NF-κB 信号通路对大鼠模型中脑缺血/再灌注诱导的损伤发挥抗炎作用[4]。
Ginkgetin (30 mg/kg；经胃内给药，每日一次，持续 42 天) 抑制携带 A549 细胞的裸鼠肿瘤生长[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g)[4] Dosage: 25, 50, 100 mg/kg Administration: I.p. 2 hours after the onset of ischemia Result: Reduced the neurological deﬁcit score.
Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
Decreased the expressions of ICAM-1, COX-2, and iNOS.
Downregulated downstream inﬂammatory factor PGE2 and TNF-α expression.
Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression. 分子量

566.51

Formula

C32H22O10

CAS 号

481-46-9

性状

固体

颜色

Light yellow to yellow

中文名称

银杏素；白果双黄酮；银杏双黄酮；银杏黄素

结构分类 Flavonoids Biflavones Phenols Polyphenols 初始来源植物银杏科银杏运输条件

Room temperature in continental US; may vary elsewhere.

储存方式 Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year 溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 20.83 mg/mL (36.77 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量 1 mg 5 mg 10 mg 1 mM 1.7652 mL 8.8260 mL 17.6519 mL 5 mM 0.3530 mL 1.7652 mL 3.5304 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器

稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

体积 (start)

浓度 (final)

体积 (final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 50% PEG300 50% Saline

Solubility: 2 mg/mL (3.53 mM); 悬浊液; 超声加热助溶

方案二

请依序添加每种溶剂： 0.5% CMC-Na/saline water

Solubility: 2 mg/mL (3.53 mM); 悬浊液; 超声助溶 (<60°C)

扫码获得
动物溶解方案

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

纯度 & 产品资料

纯度: 99.87%

选择批次：

Data Sheet (645 KB) SDS (393 KB)

COA (287 KB) HNMR (305 KB) RP-HPLC (245 KB) MS (70 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. [Content Brief]

[2]. Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. [Content Brief]

[3]. Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. [Content Brief]

[4]. Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. [Content Brief]

[5]. Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. [Content Brief]