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金线莲苷的研究现状

来源：花匠小妙招时间：2026-01-22 04:38

摘要： 金线莲苷（kinsenoside），一种从药用植物金线莲中提取的天然生物活性糖苷，已被证明具有显著的药理功效。本文通过收集金线莲苷的相关研究文章，尤其针对近几年更新发表的研究成果，整理分析后将金线莲苷的研究现状主要分为3方面，即：金线莲苷的基本信息，包括化学结构、来源物种及影响积累的因素；金线莲苷的分离提取、定性定量检测、人工合成方法总结；金线莲苷的药理作用，包括降血糖、降血脂、保肝作用及缓解骨病变等。鉴于金线莲苷的原材料资源匮乏，人工种植成本昂贵导致的市场应用受限，我们认为通过提高开唇兰属植物中金线莲苷的提取效率，开发更多含有金线莲苷的植物，或以栽培效率和人工合成技术的进步等方式解决生产实践问题。而在药理研究方面，我们支持通过在大型灵长类动物上进行剂量毒性试验，开发靶向治疗策略提高治疗准确性，以及精确金线莲苷使用的干预时间点等试验为金线莲苷在未来临床实践中的转化应用奠定基础。

关键词: 金线莲苷, 提取, 检测, 人工合成, 药理作用

Abstract:

Kinsenoside,a bioactive glycoside component extracted from the medicinal plant Anoectochilus roxburghii,has been proven to have significant pharmacological effects.This review has collected relevant literature on kinsenoside,especially for the research results published in recent years.After sorting out and analyzing,the research status of kinsenoside is mainly divided into three parts,namely the basic information of kinsenoside,including chemical structure,source species and factors affecting accumulation;summary of methods of separation and extraction,qualitative and quantitative detection,and artificial synthesis of kinsenoside;pharmacological effects of kinsenoside,including anti-hyperglycemia,anti-hyperliposis,hepatoprotection and relieve bone lesions,etc.Considering that the raw material resources of kinsenoside are scarce and the market application is limited due to high labor costs,we believe that by improving the extraction efficiency of kinsenoside in the genus Anoectochilus,developing more plants containing kinsenoside,or the improvement of cultivation efficiency and artificial synthesis technology,and other methods to solve production practice problems.In terms of pharmacological research,we support the use of dose toxicity tests on large primates,the development of targeted therapy strategies to improve the accuracy of treatment,and the precise intervention time points for the use of kinsenoside which lay the foundation for translational application in future clinical practice.

Key words: kinsenoside, extraction, detection, artificial synthesis, pharmacological effects

中图分类号: S184S326