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射干抗炎药效物质基础研究

来源：花匠小妙招时间：2026-01-02 05:02

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[摘要]

目的：探讨射干抗炎的药效物质基础。方法：采用SPSS统计分析方法，以41个色谱峰的相对峰面积为自变量，提取物对蛋清致大鼠足跖肿胀形成的抑制作用为因变量进行相关分析和回归分析，并进行了初步时效学观察。结果：得到41个色谱峰的相关系数，0.5 h时，消炎效果最好。结论：初步确定11个色谱峰所代表的化学组分为射干抗炎的药效物质基础，其中X33为鸢尾黄素，其余为未知成分，时效学实验结果提示，射干抗炎作用起效较快，但作用时间较短。

[Key word]

[Abstract]

Objective: To study the anti-inflammatory therapeutic material basis of Belamcanda chinensis. Methods: Using SPSS statistical analysis methods to 41 peaks of the relative peak area of the independent variables, extract on egg white-induced mice paw edema formation inhibition as the dependent variable for correlation analysis and regression analysis. Results: Each correlation coefficient of 40 chromatographic peaks is got，the effect of antiphlogistic is the best at 0.5 h. Conclusion: It can be preliminary determined that the 11 chromatographic peaks represented by the chemical constituent for Leontopodium have an acute anti-inflammatory pharmacodynaic material basis, which chromatographic peak that X33 is Iris flavin, and the remaining peaks are the unknown components. It suggests that the effect of antiphlogistic was quick but the effecting time was short.

[基金项目]

科技部重大专项“十一·五”重大新药创制（2009ZX09103-330）

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李国信,姜鸿,邸子真.射干抗炎药效物质基础研究[J].药物评价研究,2010,33(5):383-387

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收稿日期: 2010-03-27