植物多糖免疫调节机制研究进展

摘要： 近年来，植物多糖因其安全、高效的免疫活性特点受到国内外学者的广泛关注。本文从组织器官、细胞及分子三个水平上对植物多糖的免疫调节作用及从受体、信号分子及microRNA三个方面对近十年，尤其是近三年的国内外植物多糖免疫调节作用和机制的研究进行综述，旨在为植物多糖免疫调节更深层次的机制研究提供思路，并为新型植物多糖免疫调节药物的研发提供科学参考。

关键词: 植物多糖, 免疫调节机制, 细胞因子, microRNA

Abstract: Recent years,due to their security and efficient immune competence,plant polysaccharides have been widely concerned by scholars at home and abroad.What’s more,most plant polysaccharides with immunomodulatory effects were natural immune regulators,with the promotion of immune organ growth,activation of immune cells,activation the complement system,cytokines release and other immune regulatory functions.This review summarized the research progress on the immune regulatory effects of plant polysaccharides on the three levels of tissues:organs,cells and molecules,and the immunomodulatory mechanisms of polysaccharides from receptors,signaling pathways and microRNA.Aimed to summarize the research status and prospect the research direction of the current plant polysaccharide immunomodulatory effects and mechanisms,and pointed out the shortcomings in the current research,then provided ideas for the study of the deeper mechanism of plant polysaccharide immunomodulation,and provided a scientific reference for the development of new plant polysaccharide immunomodulatory drugs.

Key words: plant polysaccharides, immunomodulatory effects, macrophages, cytokines, microRNA

中图分类号: 

R91

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