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竹叶黄酮药理作用研究进展

来源：花匠小妙招时间：2025-05-01 07:56

[1]GONG J Y,XIA D Z,HUANG J,et al.Functional compon-ents of bamboo shavings and bamboo leaf extracts and their antioxidant activities in vitro[J].J Med Food,2015,18(4):453-459.

This study was designed to detect characteristic compounds and evaluate the free radical scavenging capacity of the bamboo leaves extract and bamboo shavings extract (BSE). The antioxidant capacity of bamboo leaf n-butanol fraction (AOB) exhibited the highest total phenolic content (49.93%), total flavonoids content (24.11%), and characteristic flavonoids and phenolic acids, such as chlorogenic acid, caffeic acid, ferulic acid, p-coumaric acid, orientin, homoorientin, vitexin, and isovitexin. Available data obtained with in vitro models suggested that AOB had higher free radical scavenging capacity with IC(50) values of 1.04, 4.48, 5.37, and 1.12 mug/mL on DPPH(*), O(2)(*-), (*)OH, and H(2)O(2), respectively, than the other two extracts, bamboo leaf water extract and BSE. The results indicated that the extracts from different parts of the bamboo possess excellent antioxidant activity, which can be used potentially as a readily accessible and valuable bioactive source of natural antioxidants.

DOI:10.1089/jmf.2014.3189 PMID:25394178 URL

[本文引用:1][2]MAO J W,YIN J,GE Q,et al.In vitro antioxidant activities of polysaccharides extracted from Moso Bamboo-Leaf[J].Int J Biol Macromol,2013,55:1-5.

The objective of this study was to evaluate in vitro antioxidant capacities of polysaccharides extracted from Moso Bamboo-Leaf (BLP). The molecular weight of the polysaccharides were obtained by SEC-LLS and their molecular masses were 13.4x10(4)Da, 2.8x10(4)Da and 1.9x10(4)Da, respectively. Available data obtained with in vitro models suggested WB1 (precipitated by 30% ethanol) showed significant inhibitory effects on superoxide radical, hydroxyl radical, DPPH radical and ferrous metal-chelating capacities. These results clearly establish the possibility that polysaccharides extracted from Moso Bamboo-Leaf could be effectively employed as ingredient in health or functional food, to alleviate oxidative stress.

DOI:10.1016/j.ijbiomac.2012.12.027 PMID:23305703 URL

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DOI:10.3390/molecules200915686 URL

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DOI:10.1016/j.ijbiomac.2017.03.124 URL

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In this study, bamboo leaf flavonoids extracts (BFE) were employed to alleviate oxidative stress induced by oleic acid in HepG2 cells. Biochemical indexes, intracellular reactive oxygen species production, lipid droplets accumulation, antioxidant enzymes production, and mitochondrial membrane potential were determined to show the alleviation performance of BFE intervention (P < 0.05). Importantly, the results of qRT-PCR and western blot determination indicated that BFE intervention upregulated the expression of Nrf2/HO-1/NQO1 to initiate the antioxidant defense response for counteracting oxidative stress (P < 0.05). Moreover, mitochondrial membrane potential-mediated apoptosis and FOXO signaling pathway initiation caused by BFE intervention may together contribute to oxidative stress alleviation in HepG2 cells. In conclusion, these findings suggested that BFE intervention upregulated related antioxidant defense responses for preventing cells from oxidative damage. PRACTICAL APPLICATION: In this study, bamboo leaf flavonoids extracts intervention upregulated related antioxidant defense responses for preventing cells from oxidative damage. These findings in bamboo leaf extracts antioxidants are a promising and innovative subject with practical applications to enhance the development of bamboo leaf extracts functional products in the food industry.

DOI:10.1111/1750-3841.14609 PMID:31116430 URL

[本文引用:1][17]GONG J,XIA D,HUANG J,et al.Functional components of bamboo shavings and bamboo leaf extracts and their antioxidant activities in vitro[J].J Med Food,2015,18(4):453-459.

DOI:10.1089/jmf.2014.3189 PMID:25394178 URL

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PMID:29906537 URL

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